Internal pallidum and substantia nigra control different parts of the mesopontine reticular formation in primate
Identifieur interne : 000169 ( France/Analysis ); précédent : 000168; suivant : 000170Internal pallidum and substantia nigra control different parts of the mesopontine reticular formation in primate
Auteurs : Anne-Sophie Rolland [France] ; Carine Karachi [France] ; Marie-Paule Muriel [France] ; Etienne C. Hirsch [France] ; Chantal François [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-08-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- Animal, Animals, Biotin (analogs & derivatives), Biotin (metabolism), Dextrans (metabolism), Globus Pallidus (physiology), Locus niger, Male, Microscopy, Electron, Transmission (methods), Monkey, Nervous system diseases, Neural Pathways (metabolism), Neural Pathways (physiology), Pallidum, Primates, Reticular Formation (anatomy & histology), Reticular Formation (physiology), Reticular formation, Substantia Nigra (physiology), Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate (metabolism), cuneiform nucleus, internal pallidum, monkeys, pedunculopontine nucleus, substantia nigra, tract tracing.
- MESH :
- chemical , analogs & derivatives : Biotin.
- chemical , metabolism : Biotin, Dextrans, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate.
- anatomy & histology : Reticular Formation.
- metabolism : Neural Pathways.
- methods : Microscopy, Electron, Transmission.
- physiology : Globus Pallidus, Neural Pathways, Reticular Formation, Substantia Nigra.
- Animals, Male, Primates.
Abstract
The locomotor area has recently emerged as a target for deep brain stimulation to lessen gait disturbances in advanced parkinsonian patients. An important step in choosing this target is to define anatomical limits of its 2 components, the pedunculopontine nucleus and the cuneiform nucleus, their connections with the basal ganglia, and their output descending pathway. Based on the hypothesis that pedunculopontine nucleus controls locomotion whereas cuneiform nucleus controls axial posture, we analyzed whether both nuclei receive inputs from the internal pallidum and substantia nigra using anterograde and retrograde tract tracing in monkeys. We also examined whether these nuclei convey descending projections to the reticulospinal pathway. Pallidal terminals were densely distributed and restricted to the pedunculopontine nucleus, whereas nigral terminals were diffusely observed in the whole extent of both the pedunculopontine nucleus and the cuneiform nucleus. Moreover, nigral terminals formed symmetric synapses with pedunculopontine nucleus and cuneiform nucleus dendrites. Retrograde tracing experiments confirmed these results because labeled cell bodies were observed in both the internal pallidum and substantia nigra after pedunculopontine nucleus injection, but only in the substantia nigra after cuneiform nucleus injection. Furthermore, anterograde tracing experiments revealed that the pedunculopontine nucleus and cuneiform nucleus project to large portions of the pontomedullary reticular formation. This is the first anatomical evidence that the internal pallidum and the substantia nigra control different parts of the brain stem and can modulate the descending reticulospinal pathway in primates. These findings support the functional hypothesis that the nigro‐cuneiform nucleus pathway could control axial posture whereas the pallido‐pedunculopontine nucleus pathway could modulate locomotion. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23705
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-08-01">2011-08-01</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1648">1648</biblScope><biblScope unit="page" to="1656">1656</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">36806541F234E2FFA814BDDF4BB688AE81D36C0E</idno><idno type="DOI">10.1002/mds.23705</idno><idno type="ArticleID">MDS23705</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Animals</term><term>Biotin (analogs & derivatives)</term><term>Biotin (metabolism)</term><term>Dextrans (metabolism)</term><term>Globus Pallidus (physiology)</term><term>Locus niger</term><term>Male</term><term>Microscopy, Electron, Transmission (methods)</term><term>Monkey</term><term>Nervous system diseases</term><term>Neural Pathways (metabolism)</term><term>Neural Pathways (physiology)</term><term>Pallidum</term><term>Primates</term><term>Reticular Formation (anatomy & histology)</term><term>Reticular Formation (physiology)</term><term>Reticular formation</term><term>Substantia Nigra (physiology)</term><term>Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate (metabolism)</term><term>cuneiform nucleus</term><term>internal pallidum</term><term>monkeys</term><term>pedunculopontine nucleus</term><term>substantia nigra</term><term>tract tracing</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Biotin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biotin</term><term>Dextrans</term><term>Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Reticular Formation</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neural Pathways</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Microscopy, Electron, Transmission</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Globus Pallidus</term><term>Neural Pathways</term><term>Reticular Formation</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Primates</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animal</term><term>Formation réticulée</term><term>Locus niger</term><term>Pallidum</term><term>Pathologie du système nerveux</term><term>Primates</term><term>Singe</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The locomotor area has recently emerged as a target for deep brain stimulation to lessen gait disturbances in advanced parkinsonian patients. An important step in choosing this target is to define anatomical limits of its 2 components, the pedunculopontine nucleus and the cuneiform nucleus, their connections with the basal ganglia, and their output descending pathway. Based on the hypothesis that pedunculopontine nucleus controls locomotion whereas cuneiform nucleus controls axial posture, we analyzed whether both nuclei receive inputs from the internal pallidum and substantia nigra using anterograde and retrograde tract tracing in monkeys. We also examined whether these nuclei convey descending projections to the reticulospinal pathway. Pallidal terminals were densely distributed and restricted to the pedunculopontine nucleus, whereas nigral terminals were diffusely observed in the whole extent of both the pedunculopontine nucleus and the cuneiform nucleus. Moreover, nigral terminals formed symmetric synapses with pedunculopontine nucleus and cuneiform nucleus dendrites. Retrograde tracing experiments confirmed these results because labeled cell bodies were observed in both the internal pallidum and substantia nigra after pedunculopontine nucleus injection, but only in the substantia nigra after cuneiform nucleus injection. Furthermore, anterograde tracing experiments revealed that the pedunculopontine nucleus and cuneiform nucleus project to large portions of the pontomedullary reticular formation. This is the first anatomical evidence that the internal pallidum and the substantia nigra control different parts of the brain stem and can modulate the descending reticulospinal pathway in primates. These findings support the functional hypothesis that the nigro‐cuneiform nucleus pathway could control axial posture whereas the pallido‐pedunculopontine nucleus pathway could modulate locomotion. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Rolland, Anne Ophie" sort="Rolland, Anne Ophie" uniqKey="Rolland A" first="Anne-Sophie" last="Rolland">Anne-Sophie Rolland</name></noRegion><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name><name sortKey="Muriel, Marie Aule" sort="Muriel, Marie Aule" uniqKey="Muriel M" first="Marie-Paule" last="Muriel">Marie-Paule Muriel</name><name sortKey="Muriel, Marie Aule" sort="Muriel, Marie Aule" uniqKey="Muriel M" first="Marie-Paule" last="Muriel">Marie-Paule Muriel</name><name sortKey="Muriel, Marie Aule" sort="Muriel, Marie Aule" uniqKey="Muriel M" first="Marie-Paule" last="Muriel">Marie-Paule Muriel</name><name sortKey="Rolland, Anne Ophie" sort="Rolland, Anne Ophie" uniqKey="Rolland A" first="Anne-Sophie" last="Rolland">Anne-Sophie Rolland</name><name sortKey="Rolland, Anne Ophie" sort="Rolland, Anne Ophie" uniqKey="Rolland A" first="Anne-Sophie" last="Rolland">Anne-Sophie Rolland</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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